Cardiovascular

Ischemia and reperfusion impact heart disease

Cardiovascular diseases are the number one cause of death globally and includes conditions such as arrhythmias, atherosclerotic vascular disease, high blood pressure, congenital heart defects, vascular dementia, and stroke. CHD is a complex condition and there are many pathways and processes involved in the pathogenesis of the disease.

Understanding the physiology of ischemia and reperfusion injury is one of the key areas of clinical interest but it has been difficult to initiate, maintain and reverse acute hypoxic environments in in-vitro studies. BMG LABTECH’s CLARIOstar Plus reader with Atmospheric Control Unit (ACU) allow oxygen levels to be rapidly and precisely controlled to mimic normal in vivo conditions, ischemia or reperfusion events, as highlighted in the AppNote: Lipid peroxidation assay in an ischemia-reperfusion cell model with NCLX inhibitors using the CLARIOstar^® Plus. Very fast reading rates of 100 measurement points/second even allow to precisely monitor cardiomyocyte contraction, e.g. by measuring the calcium flux with fluorescent dyes. Explore the content below to see how we can support ischemia-reperfusion research and cardiovascular research including investigation on what effects oxygen deprivation and reperfusion injury can have on cells, elucidating the role of various cellular processes and identifying potential drug targets to minimize the effects of patients suffering with CHD.